[Ca(2+)](i) oscillation frequency regulates agonist-stimulated NF-kappaB transcriptional activity.

In nonexcitable cells, stimulation by high agonist concentrations typically produces a biphasic increase in cytosolic Ca(2+) ([Ca(2+)](i)). This response is characterized by a transient initial increase because of intracellular Ca(2+) release followed by a sustained elevation which varies in amplitude depending on the nature of the stimulus. In contrast… CONTINUE READING