[C677T mutation in methylentetrahydrofolatereductase gene in patients with venous thromboses from the central region of Russia correlates with a high risk of pulmonary artery thromboembolism].

@article{Avdonin2006C677TMI,
  title={[C677T mutation in methylentetrahydrofolatereductase gene in patients with venous thromboses from the central region of Russia correlates with a high risk of pulmonary artery thromboembolism].},
  author={Pavel V Avdonin and Alexander I Kirienko and L. M. Kozhevnikova and Nadejda A Shostak and N M Babadaeva and S G Leont'ev and E. B. Petukhov and Aslan Amirkhanovich Kubatiev and V. S. Savel'ev},
  journal={Terapevticheskii arkhiv},
  year={2006},
  volume={78 6},
  pages={
          70-6
        }
}
AIM To investigate genetic factors of risk (RF) to develop venous thrombosis and pulmonary artery thromboembolism (PATE) in population of central Russia. MATERIAL AND METHODS We studied polymorphism of the genes of coagulation factor II (G20210A), factor V (G1691A) and methylentetrahydrofolatereductase (MTHFR) with polymerase chain reaction and restriction analysis of DNA amplified sites. We estimated prevalence of the mutations in healthy population and in patients with flebothrombosis as… CONTINUE READING

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