[C+NC+CC] coupling-enabled synthesis of influenza neuramidase inhibitor A-315675.

Abstract

An efficient synthesis of the neuramidase inhibitor A-315675 is reported. The fully functionalized pyrrolidine core of the target is assembled in one pot via an exo-selective asymmetric [C+NC+CC] coupling reaction. 
DOI: 10.1021/ol3002128

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