[C+NC+CC] coupling-enabled synthesis of influenza neuramidase inhibitor A-315675.
L. C. C. Weerasinghe
Wiley J. Youngs
Dean M. Wilson
Dylan H Jacobs
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Abstract & Figures
An efficient synthesis of the neuramidase inhibitor A-315675 is reported. The fully functionalized pyrrolidine core of the target is assembled in one pot via an exo-selective asymmetric [C+NC+CC] coupling reaction.
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