[Bone and Stem Cells. Regulation of haematopoietic stem cell maintenance and mobilization by osteoclasts].

Abstract

Haematopoietic stem cells (HSCs) are maintained in a specialized microenvironment termed "niche" in bone marrow (BM) cavities. Osteoclasts are required for formation of BM cavities, and thus, osteoclast-less animals exhibit BM cavity-less osteopetrotic phenotypes. Osteoclasts were also reportedly required for mobilization of haematopoietic stem and… (More)

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