[Biotransformation of amiodaquine and prophylaxis of Plasmodium falciparum malaria].

@article{Pussard1985BiotransformationOA,
  title={[Biotransformation of amiodaquine and prophylaxis of Plasmodium falciparum malaria].},
  author={Eric Pussard and Fr{\'e}d{\'e}ric Verdier and M. C. Blayo and J. J. Pocidalo},
  journal={Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie},
  year={1985},
  volume={301 8},
  pages={383-5}
}
The authors have devised a specific HPLC method for amodiaquine assay which demonstrated that the drug disappeared rapidly from the blood of subjects under prophylaxis for malaria (10 mg/kg/week in a single oral dose). The main metabolite was identified as the monodesethyl derivative which is the only active form of the drug. The low erythrocytic levels of the metabolite, observed at day +7, might account for the failure in the prophylaxis of P. falciparum malaria with amodiaquine in a few… CONTINUE READING

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