[Biochemical and histological changes after acute oral poisoning with the acetanilide herbicide acetochlor].

@article{Antov1991BiochemicalAH,
  title={[Biochemical and histological changes after acute oral poisoning with the acetanilide herbicide acetochlor].},
  author={G P Antov and C Zaikov and Ahmed Bouzidi and S Mitova and A Michaelova and J Halkova and N Choumkov},
  journal={Journal de toxicologie clinique et experimentale},
  year={1991},
  volume={11 6},
  pages={349-56}
}
Changes in the liver of male rats were studied on the 1, 3, 5, 7, 10 and 14 days after a single oral application of 1/5 DL 50 of the chloracetanilic herbicide Acetochlor (DL50 = 1063 mg/kg-1). Two main periods in the action of acetochlor can be identified: between 1-2 days when the influence of the compound itself is predominant and between 5-7 days, when the toxic action of the slowly eliminated metabolites is most pronounced. These two periods provoke a biphasic activation/inhibition response… CONTINUE READING

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