[Bioavailability of dalargin and its metabolism during intranasal administration to rats].

@article{Vinogradov1988BioavailabilityOD,
  title={[Bioavailability of dalargin and its metabolism during intranasal administration to rats].},
  author={V. A. Vinogradov and Elena I Kalenikova and Andrei S. Sokolov},
  journal={Biulleten' eksperimental'noi biologii i meditsiny},
  year={1988},
  volume={106 7},
  pages={
          48-50
        }
}
Bioavailability and metabolism of a peptide drug Dalargin with a chemical structure Tyr-D-Ala-Gly-Phe-Leu-Arg have been examined. Dalargin is applied for the treatment of gastric and duodenal ulcers. Bioavailability was estimated following intramuscular (i/m) and intranasal (i/n) routes of administration of 3H-dalargin in anesthetized dogs. The highest dalargin concentration was achieved about 10 min after i/m and i/n administration. Absolute dalargin bioavailability was 15% and 8%, while its… CONTINUE READING

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