Corpus ID: 23513268

[Binding of racemic indoprofen and its enantiomers to human serum albumin].

  title={[Binding of racemic indoprofen and its enantiomers to human serum albumin].},
  author={D. Siebler and A. Kinawi},
  volume={39 6},
Binding of Racemic Indoprofen and its Enantiomers to Human Serum Albumin. The binding to 2% and 4% human serum albumin (HSA) of (+/-)-indoprofen, (-)-indoprofen, and (+)-indoprofen was examined applying a modified ultrafiltration process. The binding properties to HSA were characterized by determining the unbound portions of the drug (a), the overall binding constants (K1), the free reaction energy (delta F degrees), the apparent binding constants (k*), and slope (m). The following results were… Expand
3 Citations
Protein Binding and Stereoselectivity of Nonsteroidal Anti-Inflammatory Drugs
Differences in binding between enantiomers can explain their differences in pharmacokinetics, once metabolic properties such as inversion have been taken into account. Expand
Enantioselective pharmacodynamics and pharmacokinetics of chiral non-steroidal anti-inflammatory drugs
  • A. Evans
  • Chemistry, Medicine
  • European Journal of Clinical Pharmacology
  • 2004
The non-steroidal anti-inflammatory drugs (NSAIDs) encompass a variety of structural classes, including salicylates, pyrazoles, oxicams, fenamates, arylacetic acids, and arylpropionic acids. DespiteExpand
Stereoselectivity in clinical pharmacokinetics and drug development
  • D. Campbell
  • Chemistry, Medicine
  • European Journal of Drug Metabolism and Pharmacokinetics
  • 2010
Although the world and nature appears at first sight to be symmetrical, for example, the human body, on closer inspections, it reveals itself to be asymmetric with the heart on the left hand side andExpand