[Basic principles of interpretation of hepatocellular hypertrophy in risk assessment in Japan].

@article{Yoshida2015BasicPO,
  title={[Basic principles of interpretation of hepatocellular hypertrophy in risk assessment in Japan].},
  author={Midori Yoshida and Takashi Umemura and Hiroyuki Kojima and Kaoru Inoue and Miwa Takahashi and Naoto Uramaru and Shigeyuki Kitamura and Kaori Abe and Masahiro Tohkin and Shogo Ozawa and Koichi Yoshinari},
  journal={Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan},
  year={2015},
  volume={56 2},
  pages={42-8}
}
This article provided a scientific basis for determining whether liver hypertrophy, a common change in the liver induced by xenobiotics in toxicological studies, is an adaptive or adverse event. To maintain homeostasis in the whole organism, the liver frequently responds to xenobiotic exposure by increasing metabolic capacity via nuclear receptor activation… CONTINUE READING