[BRAF gene mutation in the natural history of papillary thyroid carcinoma: diagnostic and prognostic implications].

@article{Lopes2011BRAFGM,
  title={[BRAF gene mutation in the natural history of papillary thyroid carcinoma: diagnostic and prognostic implications].},
  author={Jo{\~a}o Pedro Lopes and Elianet Fonseca},
  journal={Acta medica portuguesa},
  year={2011},
  volume={24 Suppl 4},
  pages={
          855-68
        }
}
The papillary carcinoma is the most prevalent malignant neoplasm of the thyroid gland, representing 85-90% of all cases, and its incidence has been increasing in recent years. It is relatively indolent, however other types poorly differentiated or anaplastic, are more aggressive and usually associated with poor prognosis. Approximately half of these papillary carcinomas harbor a thymine-to-adenine transversion (T1799A) point mutation, in the gene encoding the serine/threonine-kinase B-type Raf… CONTINUE READING

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Mutação do gene braf na história natural do carcinoma.

  • L LEENHARDT, P GROSCLAUDE
  • Acta Med Port
  • 2011
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