[Autologous tumor specific immunotherapy of refractory cancers with ex vivo-generated T cells stimulated by autologous tumor cell].

@article{Toh2003AutologousTS,
  title={[Autologous tumor specific immunotherapy of refractory cancers with ex vivo-generated T cells stimulated by autologous tumor cell].},
  author={Uhi Toh and Hideaki Yamana and Kouichiro Kido and Takashi Mine and Teruhiko Fujii and Hiroyuki Horiuchi and Teruo Sasatomi and Nobuya Ishibashi and Shigeru Yutani and Hiromasa Fujita and Kazuo Shirouzu},
  journal={Gan to kagaku ryoho. Cancer & chemotherapy},
  year={2003},
  volume={30 11},
  pages={
          1566-70
        }
}
OBJECTIVES Autologous tumor-cell stimulated cytotoxic T lymphocytes (AuTLs) were prepared from peripheral blood T cells and the T cells were activated ex vivo over a 2-week culturing process in the presence of IL-2 and autologous biopsied tumor-cells from advanced cancer patients. These AuTLs may have potential for efficacy as a locoregional therapy in patients with refractory cancer. METHODS Twenty-nine of 35 cancer patients (13 esophagus, 5 lung, 3 stomach, 4 breast, 1 melanoma) were… CONTINUE READING