[Autoimmune disease].

  title={[Autoimmune disease].},
  author={T. Yoshikawa and Y. Kawahito},
  journal={Nihon rinsho. Japanese journal of clinical medicine},
  volume={63 4},
Peroxisome proliferator-activated receptors (PPARs) are members for the nuclear hormone receptors superfamily of ligand-activated transcriptional factors. PPARs have diverse function for keeping physiology of the human body, such as fatty acid regulation. In particular, PPAR-alpha and -gamma, have anti-inflammatory function and play an important role in immune system. With these ligands, we can suppress inflammation and regulate abnormal immune reaction in variety of immunocompetent cells and… Expand
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A review of findings on glycosylated proteins and their cognate receptors in modulation of the autoimmune response with particular focus on sialic acid‐binding immunoglobulin‐like lectin (Siglec)‐1 and Siglec‐2 involvement in AD will help clinicians achieve remission earlier. Expand
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Recent publications that have reported how the major metabolic pathways are affected in autoimmune diseases, with a focus on rheumatic diseases are reviewed. Expand
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The role of IL-12 family members in cardiovascular diseases, and the molecular and cellular mechanisms potentially involved in their action in order to identify possible intervention targets for the prevention and clinical treatment of cardiovascular diseases are discussed. Expand
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In neuroinflammatory and neurodegenerative diseases, P2X7 upregulation and function appears to contribute to disease progression, and is highlighted as a potential target to treat inflammatory related diseases. Expand
Alpha versus beta: are we on the way to resolve the mystery as to which is the endogenous ligand for natural killer T cells?
  • Y. Ilan
  • Biology, Medicine
  • Clinical and experimental immunology
  • 2009
Data from animal models and humans on the NKT‐dependent immunomodulatory effect of beta‐glycosphingolipids and the modest effect of these ligands in human studies suggest that the beta‐anomeric ligands have the potential to be the endogenous NKT ligand. Expand
Co‐stimulatory pathways in lymphocyte regulation: the immunoglobulin superfamily
The understanding of its relevance in a variety of physio‐pathological circumstances is now yielding a number of potential targets for therapeutic manipulation, and such immunological molecular adjuvants are beginning to enter clinical trials. Expand
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Congruent Effects of Estrogen and T-Cell Receptor Peptide Therapy on Regulatory T Cells in EAE and MS
The combined effects on Treg expansion and activation induced by these distinct immunoregulatory approaches may account for their potent effects on clinical EAE and argue for a similar combined therapeutic approach for MS. Expand