[Augmentation of murine organ-associated natural immune responses by cepharanthin].

  title={[Augmentation of murine organ-associated natural immune responses by cepharanthin].},
  author={Masaya Ono and Takeshi Urabe and Yukiko Okamoto and Hirokazu Murakami and Akihiko Tatemoto and Shigekazu Ohno and Hiroyuki Yamamoto and Ryosuke Watanabe and Akio Hizuta and Noriaki Tanaka},
  journal={Gan to kagaku ryoho. Cancer & chemotherapy},
  volume={15 1},
Oral administration of cepharanthin (bisbenzylisoquinoline alkaloid) to mice was effective in the organ-associated immune responses. Cepharanthin, as a biological response modifier (BRM), augmented natural killer (NK) activity of leukocytes isolated from the spleen, lymph node, lung, and liver. The degree of NK augmentation was almost the same in these organs without lymph node, and reached to the maximum levels 3 days after cepharanthin administration. In addition, adherent leukocytes (greater… CONTINUE READING