[Atypical antipsychotic profiles of sigma receptor ligands].

  title={[Atypical antipsychotic profiles of sigma receptor ligands].},
  author={Shigeru Okuyama},
  journal={Nihon yakurigaku zasshi. Folia pharmacologica Japonica},
  volume={114 1},
  • Shigeru Okuyama
  • Published 1999 in
    Nihon yakurigaku zasshi. Folia pharmacologica…
This is a review on the recent results of research on sigma-receptor antagonists. NE-100, a selective sigma1-receptor antagonist, shows improvement of abnormal behaviors and cognitive dysfunction induced by phencyclidine (PCP). However, NE-100 does not inhibit dopamine agonist-induced behaviors nor induces catalepsy. The mode of action of NE-100 is estimated to be the indirect modulation of the NMDA/PCP-receptor ion channel complex and the modulation of dopamine release from the dopaminergic… CONTINUE READING