[Asymmetric syntheses of azacycloalkanes by one-pot [1+2+n] cyclization].

  • Shingo Harada
  • Published 2013 in
    Yakugaku zasshi : Journal of the Pharmaceutical…

Abstract

Enantio- and diastereoselective one-pot synthesis of three- to seven-membered cis-azaheterocycles was achieved using a triggered asymmetric conjugate addition reaction of lithium amide with an enoate, followed by C- and N-alkylation of the resulting lithium 3-aminoenolate with α, ω-dihaloalkane, which can be regarded as a [1+2+n] cyclization. The usefulness… (More)

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