• Medicine
  • Published in Minerva stomatologica 2003

[Association between interleukin-1 composite genotype and severe periodontitis: case-control study].

@article{Nastri2003AssociationBI,
  title={[Association between interleukin-1 composite genotype and severe periodontitis: case-control study].},
  author={Livia Nastri and F. Caruso},
  journal={Minerva stomatologica},
  year={2003},
  volume={52 6},
  pages={
          253-9
        }
}
AIM Interleukin-1 (IL-1) is a bone resorption stimulating cytokine that is implicated in the development of periodondal lesions. Recent studies suggest that the production of this mediator depends for quantity on a specific allelic combination in its genetic cluster. Periodontitis severity was correlated with the extent of the form 2 allele at the position -889 in the gene IL-1A, together with the form 2 allele at the position +3953 of the gene IL-1B. Aim of the study was to evaluate the… CONTINUE READING