[Assay method for uracil, dihydrouracil, 5-fluorouracil and 5-fluoro-5, 6-dihydrouracil by high-performance liquid chromatography].

@article{Nakamura2004AssayMF,
  title={[Assay method for uracil, dihydrouracil, 5-fluorouracil and 5-fluoro-5, 6-dihydrouracil by high-performance liquid chromatography].},
  author={Aki Nakamura and Kazuo Kikuchi and Takayoshi Ohishi and Taketoshi Masuike},
  journal={Gan to kagaku ryoho. Cancer & chemotherapy},
  year={2004},
  volume={31 3},
  pages={381-6}
}
In humans, 80-90% of the administered dose of 5-fluorouracil (5-FU) is degraded by dihydropyrimidine dehydrogenase (DPD), the initial rate-limiting enzyme in pyrimidine catabolism. In a previous report, the concentration ratio of uracil (U) and its dihydrogenated metabolite dihydrouracil (DHU) in human plasma before 5-FU treatment was found to be useful as an index of optimal 5-FU dosage, and was reported to be helpful in identifying patients with metabolic deficiency and anticipated risk of… CONTINUE READING