[Apoptosis of human melanoma cell line WM-983A by p16 gene transduction].

  title={[Apoptosis of human melanoma cell line WM-983A by p16 gene transduction].},
  author={Jing-ning Cheng and Chen Lin and Rong Xing},
  journal={Zhonghua zhong liu za zhi [Chinese journal of oncology]},
  volume={21 2},
OBJECTIVE To further understand the mechanism of action of the tumor-suppressor gene p16. METHODS An adenoviral expression vector with full length cDNA of p16 gene insert was constructed (Ad-p16) and transfected into WM-983A cells, the p16 gene of which was point mutated at codon 126. The effect of exogenous p16 gene on the growth of WM-983A cells was examined in vitro and in vivo. RESULTS Expression of p16 gene in WM-983A cells was confirmed by Western blot. The in vitro growth of the Ad… CONTINUE READING

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