[Apoptosis induced by cantharidin in human pulmonary carcinoma cells A549 and its molecular mechanisms].

@article{Zhang2005ApoptosisIB,
  title={[Apoptosis induced by cantharidin in human pulmonary carcinoma cells A549 and its molecular mechanisms].},
  author={Weidong Zhang and Hui-ru Zhao and Ying Yan and Xiaohua Wang and Zhi-hong Zong and Ying Liu},
  journal={Zhonghua zhong liu za zhi [Chinese journal of oncology]},
  year={2005},
  volume={27 6},
  pages={330-4}
}
OBJECTIVE To investigate the apoptosis-inducing effect of cantharidin in human lung cancer cells A549 and its molecular mechanisms. METHODS MTT assay was used to determine A549 cells proliferation. Light and electron microscopy, FACScan, Annexin V-FITC staining and DNA gel electrophoresis were used to detect apoptosis. The expression of bcl-2, Bax and survivin were examined by Western blot. RESULTS Cantharidin inhibited the proliferation of A549 cells. The cells treated with cantharidin… CONTINUE READING