Corpus ID: 33675690

[Antitumor activity of the new gestagen 17alpha-acetoxy-3beta-butanoyloxy-6-methyl-pregna-4,6-dien-20-one].

  title={[Antitumor activity of the new gestagen 17alpha-acetoxy-3beta-butanoyloxy-6-methyl-pregna-4,6-dien-20-one].},
  author={P. Sergeev and A. V. Semeikin and Z. Smirnova and V. M. Rzheznikov and G. S. Grinenko and A. Fedosov and T. A. Fedotcheva and N. Shimanovskii},
  journal={Eksperimental'naia i klinicheskaia farmakologiia},
  volume={67 4},
Antitumor activity of a new highly active promising gestagen 17alpha-acetoxy-3beta-butanoyloxy-6-methyl-pregna-4,6-dien-20-one (butagest) was studied in mice with model cervical carcinoma (RShM-5). The reference drug was medroxyprogesteron acetate (MPA, Depo Provera) used in clinics. The new preparation introduced perorally in a dose of 1 mg per mice inhibited the model tumor growth by 73%, which was 18% (p < 0.01) more effective than the action of the reference drug MPA. The effect of the new… Expand
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