Corpus ID: 38819121

[Antihypertensive and diuretic effects of indapamide in normotensive and hypertensive rats (author's transl)].

@article{Morishita1982AntihypertensiveAD,
  title={[Antihypertensive and diuretic effects of indapamide in normotensive and hypertensive rats (author's transl)].},
  author={S. Morishita and K. Nishimura and E. Kato and H. Shirahase and S. Osumi and K. Kitao and T. Seki},
  journal={Nihon yakurigaku zasshi. Folia pharmacologica Japonica},
  year={1982},
  volume={79 3},
  pages={
          137-46
        }
}
Antihypertensive and diuretic actions of indapamide (SE-1520) were investigated in rats and compared with those of trichlormethiazide (TCMT). In normotensive rats, indapamide in a dose of 100 mg/kg p.o. did not show a significant effect on the blood pressure. In DOCA-saline and uni-nephrectomized DOCA-saline hypertensive rats, indapamide above 1 mg/kg and TCMT above 3 mg/kg with single oral or repetitive administration for 2 weeks reduced the blood pressure level. In spontaneously hypertensive… Expand
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