[Anti-leukotriene agents: rationale for and prospects of use].

Abstract

Leukotrienes (LT) are synthesized from arachidonic acid by several enzymes such as phospholipase A2, 5-lipoxygenase, LTC4 synthase, as a consequence of a wide range of inflammatory stimuli. Leukotrienes seem to play a pivotal role in the maintenance of the inflammatory processes as they exert numerous biological activities, i.e. chemotactic action on… (More)

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