Corpus ID: 12469726

[Anti-inflammatory effect of ACTH in the rat].

  title={[Anti-inflammatory effect of ACTH in the rat].},
  author={R Seghaye and E. Deflandre and G. Remacle-Volon and Jacques Damas},
  journal={Comptes rendus des seances de la Societe de biologie et de ses filiales},
  volume={180 3},
In rats, ACTH reduced the oedemas induced by zymosan and lambda carrageenan. ACTH reduced the volume of the exudate induced by sponge implantation and its content in proteins, beta-galactosidase, beta-glucuronidase and PGE2. The inhibitory effect of ACTH was suppressed by adrenalectomy which increased the carrageenan-oedema. The inhibitory effect of ACTH was also suppressed by 17 alpha-methyltestosterone. Corticosterone reduced carrageenan-oedema. The inhibitory effect of corticosterone was… Expand
Contribution of adrenal hormones to nicotine‐induced inhibition of synovial plasma extravasation in the rat
It is found that nicotine dose‐dependently inhibited bradykinin (BK)‐ and platelet activating factor (PAF)‐induced plasma extravasation and naloxone attenuated the inhibitory action produced by all doses of nicotine on BK‐ or PAF‐induced PlasmaExtravasation, suggesting the contribution of endogenous opioids. Expand