[Animal sensitivity to the diabetogenic action of alloxan during cold adaptation].


During cold adaptation, the rats demonstrate a significant decrease in plasma immunoreactive insulin (IRI), with glucose concentration remaining invariable. Injection of alloxan (170 mg/kg bw) to control rats causes death of 58% of animals. Survived rats show stable hyperglycemia and a considerable fall of plasma IRI. The insular apparatus of the pancreas… (More)