[Angiotensin type 2 receptor-dependent vasodilation].

  title={[Angiotensin type 2 receptor-dependent vasodilation].},
  author={Katsutoshi Yayama and Hiroshi Okamoto},
  journal={Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan},
  volume={127 9},
Angiotensin II (Ang II) signaling is mediated by two receptor subtypes, type 1 (AT(1)) and type 2 (AT(2)). The activation of AT(1) receptors is responsible for the development of Ang II-dependent hypertension, whereas the activation of AT(2) receptor is thought to play a counter-regulatory protective role in the regulation of blood pressure that opposes the AT(1) receptor-mediated vasoconstriction. However, the precise mechanisms by which increased numbers of AT(2) receptors counterbalance the… CONTINUE READING
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