[Anatomo-pathologic lesions and gas exchange abnormalities in COPD].

Pulmonary emphysema and bronchiolar abnormalities are the most characteristic histological lesions in chronic obstructive pulmonary disease (COPD). Hypoxemia and hypercapnia are mainly due to ventilation-perfusion mismatching. Under stable clinical conditions, both intrapulmonary shunt and limitation of oxygen transport from the alveoli to the capillary do… (More)