[Analysis of the physico-chemical properties of fluorocarbon inducers of cytochrome P-450 in membranes of liver endoplasmic reticulum].

@article{Obraztsov1988AnalysisOT,
  title={[Analysis of the physico-chemical properties of fluorocarbon inducers of cytochrome P-450 in membranes of liver endoplasmic reticulum].},
  author={Viktor V Obraztsov and D. G. Shekhtman and Alla Nikolaevna Sklifas and Kirill Nikolaevich Makarov},
  journal={Biokhimiia},
  year={1988},
  volume={53 4},
  pages={
          613-9
        }
}
Cytochrome P-450 induction in rat liver microsomes after intravenous injections of submicrone emulsions of nine perfluorochemicals (2 g of PFC per kg of body weight) was investigated. A comparison of physico-chemical properties of the fluorocarbons revealed that their activity as cytochrome P-450 inducers is determined by their solubility in H2O and lipids as well as by the pressure of their saturated vapours at 37 degrees C. The fluorocarbons capable of inducing cytochrome P-450 have a… CONTINUE READING

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