[Analysis of patients with positive acid-fast bacilli culture and negative T-SPOT.TB results].

@article{Han2010AnalysisOP,
  title={[Analysis of patients with positive acid-fast bacilli culture and negative T-SPOT.TB results].},
  author={You Mie Han and Hyun Soo Kim and Cheol-Hong Kim and Hee Jung Kang and Kyu Man Lee},
  journal={The Korean journal of laboratory medicine},
  year={2010},
  volume={30 4},
  pages={
          414-9
        }
}
  • Y. Han, H. S. Kim, +2 authors K. Lee
  • Published 1 August 2010
  • Medicine
  • The Korean journal of laboratory medicine
BACKGROUND T-SPOT.TB is a sensitive test that detects interferon-gamma producing T-cells in tuberculosis patients following stimulation with tuberculosis-specific antigens. Our study was aimed to investigate the possible causes of false negative results of the test by analyzing the patients with positive acid-fast bacilli (AFB) culture and negative T-SPOT.TB results. METHODS We investigated 138 patients with positive AFB culture results reported between January 2009 and April 2010. Medical… 
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6 Citations

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Citation Type

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References

SHOWING 1-10 OF 10 REFERENCES
[Clinical usefulness of T-SPOT.TB test for the diagnosis of tuberculosis].
TLDR
Clinical usefulness of T-SPOT.TB test in Korean adults with intermediate burden of tuberculosis and high rate of BCG vaccination at birth is evaluated and positive results should be cautiously interpreted because of high positivity in treated tuberculosis patients and healthy volunteers in Korea.
Comparison of two commercial interferon-γ assays for diagnosing Mycobacterium tuberculosis infection
TLDR
While some differences were found in the performance of the two commercialised interferon-γ assays, they seemed to be superior in their detection of Mycobacterium tuberculosis infection compared with tuberculin skin tests.
False negative results of QuantiFERON TB-2G test in patients with active tuberculosis.
TLDR
It is suspected that there are two patterns by which false negative results are shown on QFT-2G tests; one pattern involves the decrease of interferon-gamma production due to advanced patient age or lymphocytopenia, and in the other lymphocytes cannot produce interfer ongamma for Mycobacterium tuberculosis-specific antigen in young patients without underlying disease.
Diagnosis of Mycobacterium tuberculosis Infection using Ex-vivo interferon-gamma Assay
TLDR
The development of new diagnostic tools, using the Mycobacterium tuberculosis-specific early secreted antigenic target 6 (ESAT-6) and culture filtrate protein 10 (CFP-10) antigens, should improve the control of tuberculosis by allowing a more accurate identification of a latent TB infection (LTBI).
Usefulness of Whole-Blood Interferon-γ Assay and Interferon-γ Enzyme-Linked Immunospot Assay in the Diagnosis of Active Pulmonary Tuberculosis
TLDR
The supplementary role of these tests for the diagnostic exclusion of active TB, although the low PPV limits their usefulness in routine clinical practice in South Korea, where the prevalence of latent TB infection is considerable.
Diagnosis and Treatment of Nontuberculous Mycobacterial Lung Disease
TLDR
Treating NTM lung diseases can be extremely difficult and factors such as patient`s age, comorbid conditions, and progression rates of symptoms and disease should be considered in the decision of treatment.
Reference Values for CD4+ and CD8+ T Lymphocytes with Naïve or Memory Phenotype and Their Association with Mortality in the Elderly
TLDR
The impact of immune parameters on survival demonstrated that only the absolute number of CD8 memory T cells, after adjustment for age, correlated with increased mortality.
False-negative results by enzyme-linked immunospot assay for interferon-gamma among patients with culture-confirmed tuberculosis.
Nontuberculous Mycobacterial Lung Disease
Survey on Changes in Mycobacterial Testing Practicies in Korean Laboratories.