[An improved novel method of venlafaxine synthesis].

Abstract

OBJECTIVE To synthesize venlafaxine with an improved novel method. METHODS p-methoxypheny lethyl-acid was reacted with SOCl(2) to produce acyl chloride which was reacted with N,N-dimethylamine solution to get amide; then through Ivanov reaction and reduction by KBH(4)/BF(3).Et(2)O to yield venlafaxine. RESULT Venlafaxine was successfully synthesized by… (More)

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