[An effective method for the estimation and comparison of the ED50 with small sample sizes].

  • M Berres
  • Published 1991 in Journal of experimental animal science


In ED50 experiments the relationship between dose and probability of response is often modelled by the probit function. Standard statistical analysis estimates the parameters of this function by the maximum likelihood principle and derives the ED50 and its fiducial limits from these parameters. Bayesian analysis is more effective in two respects: It… (More)


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