[An antisense oligodeoxynucleotides for NR1 suppressed seizures and reduced discharges in the temporal cortex slice in genetically epilepsy-prone rat].

Abstract

OBJECTIVE To investigate the effects of N-methyl-D-aspartate receptors (NMDAR or NR) and NR1 subunit on mechanism of initiation and development epilepsy of genetically epilepsy-prone rat. METHODS Antisense oligodeoxynucleotices (ODN) techniques, intracerebroventricular injection and experiments in vitro in rat temporal cortex slices were used. RESULTS… (More)

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