[Aging changes of gelatinase activity in kidney tissue of autoimmune MRL/lpr mice].

OBJECTIVE To determine whether increased expressions of gelatinases occur with aging in vivo in kidney tissue of autoimmune MRL/lpr mice by in situ zymography. METHODS MRL/lpr mice at the age of 8 weeks, 16 weeks and 24 weeks were investigated. Kidney protein extracts were compared for activities of MMP-2/9 by gelatin zymography. Immunohistochemistry and… CONTINUE READING