[Acyclic nucleoside analogs: synthesis and cytotoxic properties of acyl derivatives of 3'(5')-amino-3'(5')-deoxy-2',3'-secoadenosine].

@article{Goriunova1995AcyclicNA,
  title={[Acyclic nucleoside analogs: synthesis and cytotoxic properties of acyl derivatives of 3'(5')-amino-3'(5')-deoxy-2',3'-secoadenosine].},
  author={O V Goriunova and I V Iartseva and Tatjana Ivanova and N A Mashalova and B. S. Kikot' and S Ia Mel'nik},
  journal={Bioorganicheskaia khimiia},
  year={1995},
  volume={21 8},
  pages={617-24}
}
Interaction of 3'-amino-3'-deoxy-2',3'-secoadenosine with the N-hydroxysuccinimide esters of nicotinic or quinaldic acids and with 1-nitroanthraquinone-2-carboxylic acid in the presence of 2-ethoxy-1-ethoxy-carbonyl-1,2-dihydroquinoline led to the corresponding amides. To obtain 5'-modified 2',3'-secoadenosine analogs, 5'-deoxy-5'-nicotinoylamido-, 5'-deoxy-5'-(quinoline-2- carbonylamido)-, and 5'-deoxy-5'-[3-(3-indolyl)propionylamido]adenosine were subjected to the periodate oxidation--sodium… CONTINUE READING