[Activation of polymorphonuclear neutrophils by contact with collagen I and degradation of collagen].

Abstract

The contact of polymorphonuclear neutrophils with type I collagen molecules triggers the production of oxygen free radicals by these cells. This activation requires two short collagenic sequences and seems to involve a beta 2 integrin on the neutrophil membrane. Oxygen free radicals are capable to degrade collagen molecules into small peptides. This… (More)

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