Corpus ID: 40008928

[Activating protein kinase C enhances ventricular action potential duration restitution and increase arrhythmia susceptibility in Langendorff-perfused rabbit hearts].

@article{Liu2012ActivatingPK,
  title={[Activating protein kinase C enhances ventricular action potential duration restitution and increase arrhythmia susceptibility in Langendorff-perfused rabbit hearts].},
  author={T. Liu and M. Qin and H. Hu and H. Huang and C. Huang},
  journal={Zhonghua xin xue guan bing za zhi},
  year={2012},
  volume={40 9},
  pages={
          780-5
        }
}
  • T. Liu, M. Qin, +2 authors C. Huang
  • Published 2012
  • Medicine
  • Zhonghua xin xue guan bing za zhi
  • OBJECTIVE To determine effects of activating protein kinase C (PKC) on ventricular action potential duration restitution (APDR) and Burst stimulus induced arrhythmia in Langendorff-perfused rabbit hearts. METHODS Male rabbits were equally divided into three groups randomly: control group (Tyrode's solution perfusion), PKC agonist phorbol-12-myristate-13-acetate (PMA, 100 nmol/L) group and PKC inhibitor bisindolylmaleimide (BIM, 500 nmol/L) group. Thirty minutes after perfusion, the monophasic… CONTINUE READING
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