[Activated protein C resistance--a recently discovered hereditary thrombophilia].

@article{Moland1998ActivatedPC,
  title={[Activated protein C resistance--a recently discovered hereditary thrombophilia].},
  author={L Moland and Per M Sandset},
  journal={Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke},
  year={1998},
  volume={118 23},
  pages={3590-5}
}
Activated protein C resistance is an inherited thrombophilia caused by a point mutation in the factor V gene (G to A transition in nucleotide 1691 in the factor V gene with replacement of arginine (R) 506 by glutamine (Q) in the factor V molecule). The mutation is commonly named factor V R506Q or factor V Leiden. The mutation results in a poor anticoagulant response to activated protein C. APC resistance is inherited autosomally, and approximately 5-10% of the Norwegian population are carriers… CONTINUE READING

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