[Action of tubocurarine on non-activated nicotinic cholinoreceptors of neurons of sympathetic ganglia in the rat].

Abstract

Mechanism of tubocurarine (Tc) action on nonactive nicotinic acetylcholine receptors (NAChRs) of rat sympathetic neurons was studied by means of the patch-clamp whole-cell method. It was found that the blocking action of Tc on nonactive NAChRs augmented with the membrane hyperpolarization. The rate constant of Tc binding to nonactive NAChR (k + B) and the… (More)

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