[Aberrant promoter methylation as biomarker for molecular cytological diagnosis of lung cancer].

@article{Grote2006AberrantPM,
  title={[Aberrant promoter methylation as biomarker for molecular cytological diagnosis of lung cancer].},
  author={Hans Juergen Grote},
  journal={Verhandlungen der Deutschen Gesellschaft fur Pathologie},
  year={2006},
  volume={90},
  pages={216-26}
}
Aberrant promoter methylation represents a main mechanism of tumor suppressor gene inactivation and may serve as a new source for biomarker discovery. This study investigated its applicability as a molecular tool for lung cancer diagnostics on bronchial aspirates. A methylation assay was developed applying a quantitative methylation specific real-time PCR (QMSP). A total of 552 patients with the differential diagnosis of lung cancer were investigated. The QMSP findings on bronchial aspirates… CONTINUE READING