• Corpus ID: 25895554

[AP-1 mediated signal transduction in thrombin-induced regulation of PAL-1 expression in human mesangial cells].

@article{Chen2000AP1MS,
  title={[AP-1 mediated signal transduction in thrombin-induced regulation of PAL-1 expression in human mesangial cells].},
  author={X M Chen and Q. He and W. Liu and Q. Xu and Yizhou Ye and Bo Fu and L. Yu},
  journal={Chinese medical journal},
  year={2000},
  volume={113 6},
  pages={
          514-9
        }
}
  • X. Chen, Q. He, L. Yu
  • Published 1 June 2000
  • Biology, Medicine
  • Chinese medical journal
OBJECTIVE To evaluate activator protein-1 (AP-1) mediated mechanisms in thrombin-induced qlasminogen activator inhibitor-1 (PAI-1) expression in cultured human glomerular mesangial cells (MCs). METHODS Electrophoretic mobility shift assay (EMSA) was employed to assess AP-1 DNA-binding activity, and Western blot hybridization was used for quantification of c-fos and c-jun, two subunits of AP-1 dimers. PAI-1 activity and mRNA expression were analysed by the fibrin plate assay and Northern… 
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