[ACE gene I/D-polymorphism and hereditary predisposition to myocardial infarction].

@article{Malygina2002ACEGI,
  title={[ACE gene I/D-polymorphism and hereditary predisposition to myocardial infarction].},
  author={N. M. Malygina and Irina V. Kostomarova and Anton Melent'ev and I. A. Melent'ev and R. T. Saigitov and G V Deriagin and Ludmila D. Serova},
  journal={Klinicheskaia meditsina},
  year={2002},
  volume={80 8},
  pages={
          25-9
        }
}
The authors compare distribution of genotype frequencies and alleles of I/D of ACE gene polymorphism in patients with various forms of ischemic heart disease (IHD): with acute myocardial infarction (MI), stable effort angina (functional class II-III); in patients with postinfarction cardiosclerosis (PICS). A relationship was found between I/D polymorphism and acute MI. Frequency of DD genotype in MI patients was 0.57, in controls--0.21, p < 0.0001, RR = 4.9. The DD genotype may serve a marker… CONTINUE READING

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