[A xenogeneic acellularized matrix for heart valve tissue engineering: in vivo study in a sheep model].

@article{Leyh2003AXA,
  title={[A xenogeneic acellularized matrix for heart valve tissue engineering: in vivo study in a sheep model].},
  author={Rainer G. Leyh and Mathias Wilhelmi and Axel Haverich and H. Mertsching},
  journal={Zeitschrift fur Kardiologie},
  year={2003},
  volume={92 11},
  pages={938-46}
}
BACKGROUND The ideal scaffold material for tissue engineered heart valves is discussed controversially. We evaluated acellularized xenogenic matrix constructs with and without seeding with autologous vascular cells in the pulmonary circulation in a sheep model. METHODS Porcine pulmonary valve conduits (n=16) were acellularized by trypsin/ EDTA incubation. Autologous myofibroblasts and endothelial cells were harvested from carotid arteries; xenogenic valve conduits (n=10) were repopulated with… CONTINUE READING