[A trial of sustained-release anticancer chemotherapy with silicone].


Mitomycin C (MMC) was incorporated into liquid silicone which was then vulcanized into solid form. Pellets of MMC were implanted at 5 different sites within the mediastinum of 9 dogs. Implants were removed at regular intervals after sacrificing the test animals. Though the mean doses of MMC released leveled off during 4 weeks, it began to increased rapidly… (More)


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