[A new series of antiparasitic organic arsenicals: the spiroarsoranes. Experimental trypanocidal activity].

@article{Dreyfuss1988ANS,
  title={[A new series of antiparasitic organic arsenicals: the spiroarsoranes. Experimental trypanocidal activity].},
  author={Georges Dreyfuss and P R Loiseau and Jack Wolf and Christian Bories and Philippe Gayral and J A Nicol{\'a}s},
  journal={Bulletin de la Societe de pathologie exotique et de ses filiales},
  year={1988},
  volume={81 3 Pt 2},
  pages={561-70}
}
Arsenical compounds are the main therapeutic way, effective in the neurological phase of trypanosomiasis. Unfortunately, their important toxicity prevents their easy administration. Structural cyclization of arsonic acid derivatives has led to a class of non-toxic compounds: spiroarsoranes. A 47 compound primary screening on an in vivo murine model of Trypanosoma brucei brucei resulted in the isolation of a very effective derivative after a single subcutaneous injection of 30 mg.kg-1 body… CONTINUE READING