[A new role of uric acid as an antioxidant in human plasma].

@article{Hasegawa1989ANR,
  title={[A new role of uric acid as an antioxidant in human plasma].},
  author={Takaaki Hasegawa and Makoto Kuroda},
  journal={Rinsho byori. The Japanese journal of clinical pathology},
  year={1989},
  volume={37 9},
  pages={
          1020-7
        }
}
Free radical attack upon uric acid (UA) nonenzymatically generates allantoin (ALT), and the presence of ALT in human plasma suggests free radical intervention within the body. To assess this possibility, we determined plasma ALT in patients with chronic renal failure (CRF) and some other diseases by high-performance liquid-chromatography (HPLC). Heparinized blood samples were obtained from 15 healthy controls, CRF patients under conservative management (n = 13) or hemodialysis (HD) treatment (n… CONTINUE READING
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