[A new potential promoter region of the human connexin 26 gene].

OBJECTIVE To explain regulatory mechanism of the human connexin 26(Cx26) gene. METHODS A DNase-1 hypersensitive 1.6 kb fragment upstream of the 5'-terminus of the Cx26 gene was sequenced and assayed with CAT reporter system. RESULTS The Cx26-1.6 kb sequence serves as a powerful promoter. CONCLUSION The Cx26-1.6 kb fragment contains two GT boxes… CONTINUE READING