[A new orally active anti-rheumatic drug targets IL-15 and IL-17].

  • Kenji Chiba
  • Published 2007 in
    Nihon Rinsho Men'eki Gakkai kaishi = Japanese…


Over production of interleukin (IL)-15 and IL-17 was observed in synovial fluids of rheumatoid arthritis (RA) patients. IL-15 activates T cells and induces IL-17 production whereas IL-17 stimulates synoviocytes to release several mediators of inflammation including IL-6, TNF-alpha, IL-8, and CCL2. Thus, it is presumed that IL-15 and IL-17 play important… (More)


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