[A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump].

@article{Tanaka1997ANM,
  title={[A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump].},
  author={Mayumi Tanaka and Yoshimasa Katoh and Hiroyuki Kawashima},
  journal={Nihon yakurigaku zasshi. Folia pharmacologica Japonica},
  year={1997},
  volume={110 1},
  pages={11-7}
}
Gastric ulcers were produced in male Donryu rats (8-weeks-old) by subserosal injection of 20 microliters of 20% acetic acid. Five days later, an indomethacin (IND)-filled osmotic pump (OP) was implanted into the dorsal subcutaneous space in the rats and maintained for 2, 3 or 4 weeks. The natural healing of the acetic acid-induced ulcers was significantly (P < 0.05) delayed by administration of IND via OP implanted for 4 weeks. Two, 3 and 4 weeks after OP implantation, the plasma IND levels was… CONTINUE READING