[A new method for 5, 10-methylenetetrahydrofolate reductase single nucleotide polymorphisms genotyping used to study susceptibility of hematological malignancy].

@article{Chen2006ANM,
  title={[A new method for 5, 10-methylenetetrahydrofolate reductase single nucleotide polymorphisms genotyping used to study susceptibility of hematological malignancy].},
  author={Baoan Chen and Ni Jiang and Menghao Ji and Peng Hou and Zu-hong Lu and Chong Shou Gao and Jia-hua Ding and Yun-yu Sun and Jun Wang and Jian Cheng and Gang Zhao},
  journal={Zhongguo shi yan xue ye xue za zhi},
  year={2006},
  volume={14 6},
  pages={1069-73}
}
The aim of this study was to set up a new method for 5, 10-Methylenetetrahydrofolate reductase (MTHFR) single nucleotide polymorphisms (SNP) genotyping, and to investigate the hereditary susceptibility of hematological malignancy. Prepared an aimed gene microarray based on cDNA microarray theory, dual-color fluorescence hybridization was used to detect SNP loci, and DNA sequencing was performed to confirm the results. The MTHFR C677T SNP loci of 157 controls and 127 patients with hematological… CONTINUE READING