[A new lupin alkaloid, (-)-leontalbinine N-oxide, in Sophora flavescens var. angustifolia seeds and its synthesis by biomimetic transformation from (+)-matrine N-oxide].

@article{Sekine1993ANL,
  title={[A new lupin alkaloid, (-)-leontalbinine N-oxide, in Sophora flavescens var. angustifolia seeds and its synthesis by biomimetic transformation from (+)-matrine N-oxide].},
  author={Toshikazu Sekine and Kyoko Saito and Rie Minami and Noriko Arai and Hiroshi Suzuki and Yasunori Koike and Isamu Murakoshi},
  journal={Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan},
  year={1993},
  volume={113 1},
  pages={53-62}
}
The possibility of the biomimetic transformation of (+)-matrine N-oxide, a main alkaloid in Sophora flavescens var. angustifolia, under various oxidative conditions was examined by the use of several metallic ions. When (+)-matrine N-oxide was warmed with FeSO4, or Fe(COOH)2 in MeOH-H2O at 40 degrees C, (-)-7, 11-didehydromatrine [(-)-leontalbinine], a minor alkaloid in the same plant, was obtained along with (+)-matrine. This selective formation of (-)-leontalbinine seems to be specific to the… CONTINUE READING