[A new class of soluble guanylate cyclase activators, generating nitric oxide].


Derivatives of diazetidine-di-N-oxides have been found capable nonenzymatic generation of nitric oxide by a principally new mechanism of nitric oxide splitting at physiological values of pH. The effects of the synthesized compounds on human platelet soluble guanylate cyclase activity have been studied. Four of seven derivatives exhibited a distinct… (More)


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